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- FOXM1 Gene - GeneCards | FOXM1 Protein | FOXM1 Antibody
FOXM1 (Forkhead Box M1) is a Protein Coding gene Diseases associated with FOXM1 include Hepatocellular Carcinoma and Alagille Syndrome 1 Among its related pathways are Signaling by ALK in cancer and Loss of Nlp from mitotic centrosomes
- Regulation of the master regulator FOXM1 in cancer - PMC
FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis
- Targeting FOXM1 condensates reduces breast tumour growth and . . . - Nature
FOXM1 is transcriptionally super-active towards oncogenic targets in a phase-separated state, and we revealed a mechanism for the role of FOXM1 LLPS-mediated FKH-DNA binding We identified
- FOXM1: A Multifunctional Oncoprotein and Emerging Therapeutic . . . - PubMed
As a master transcriptional regulator, FOXM1 promotes critical oncogenic phenotypes in ovarian cancer, including: (1) cell proliferation, (2) invasion and metastasis, (3) chemotherapy resistance, (4) cancer stem cell (CSC) properties, (5) genomic instability, and (6) altered cellular metabolism
- FOXM1: A key oncofoetal transcription factor in health and disease
Forkhead Box M1 (FOXM1) is a bona fide oncofoetal transcription factor, which orchestrates complex temporal and spatial gene expression throughout embryonic and foetal development as well as during adult tissue homeostasis and repair
- FOXM1: An emerging master regulator of DNA damage response and . . .
FOXM1 is a potent oncogenic factor essential for cancer initiation, progression and drug resistance FOXM1 also drives the transcription of genes for DNA damage sensors, mediators, signal transducers and effectors It plays an integral part in maintaining the integrity of the genome
- FoxM1: a Master Regulator of Tumor Metastasis - PMC
FoxM1 directly activates genes involved in multiple steps of metastasis In this review, we discuss the evidence for a master regulatory role of FoxM1 in tumor metastasis FoxM1 belongs to a large family of forkhead box (Fox) transcription factors
- The transcription factor FOXM1 (Forkhead box M1 . . . - PubMed
FOXM1 is a transcriptional activator with a forkhead domain as DNA binding domain and with a very strong acidic transactivation domain However, wild-type FOXM1 is (almost) inactive because the transactivation domain is repressed by three inhibitory domains
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