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- A noncanonical function of cGAMP in inflammasome priming and . . .
Although it is unexpected that a cell would have cytosolic 2′3′-cGAMP without also finding cytosolic DNA present, we have been able to discern the role of cGAMP in enhancing the DNA-induced Aim2 inflammasome using knockout mice and transfection of cGAMP without additional DNA
- Pivotal roles of cGAS-cGAMP signaling in antiviral defense . . .
Here, we show that cells from cGAS-deficient (cGas(- -)) mice, including fibroblasts, macrophages, and dendritic cells, failed to produce type I interferons and other cytokines in response to DNA transfection or DNA virus infection cGas(- -) mice were more susceptible to lethal infection with herpes simplex virus 1 (HSV1) than wild-type mice
- LL-37 transports immunoreactive cGAMP to activate STING . . .
LL-37 specifically binds cGAMP and efficiently delivers cGAMP into target cells cGAMP transferred by LL-37 activates robust interferon responses and host antiviral immunity in a STING-dependent manner
- Structures of ATP-binding cassette transporter ABCC1 reveal . . .
Cyclic nucleotide GMP-AMP (cGAMP) plays a critical role in mediating the innate immune response through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway Recent studies showed that ATP-binding cassette subfamily C member 1 (ABCC1) is a cGAMP exporter
- ABCC1 transporter exports the immunostimulatory cyclic . . .
We demonstrate that ABCC1 deficiency exacerbated cGAS-dependent autoimmunity in the Trex1− − mouse model of Aicardi-Goutières syndrome Thus, ABCC1-mediated cGAMP export is a key regulatory mechanism that limits cell-intrinsic activation of STING and ameliorates STING-dependent autoimmune disease
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